Motility as a virulence factor for Vibrio cholerae
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چکیده
منابع مشابه
Motility as a virulence factor for Vibrio cholerae.
The ability of motile strains of the Ogawa and Inaba serotypes of classical Vibrio cholerae and of the El Tor biotypes to kill suckling mice after oral challenge with 10-8 colony-forming units (representing at least 100 to 1,000 minimal lethal doses) was compared to that of nonmotile derivatives of the same strains. Loss of motility, in each case, resulted in a marked reduction in virulence. Th...
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A simple method for concentrating, isolating, and purifying PF/cholera enterotoxin from culture supernatant fluids is presented. Precipitation with dextran sulfate and ammonium sulfate, followed by gel filtration and ion-exchange chromatography, yielded PF/enterotoxin of high biological potency. Although not completely free from traces of vibriocidal antibody-stimulating activity, the resultant...
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Vibrio cholerae is a Gram-negative bacterium with a single sheathed polar flagellum (Fig. 1.). V. cholerae causes the severe diarrheal disease cholera in humans when it colonizes the small intestine and expresses various virulence factors, including cholera toxin (CT) and toxin coregulated pilus (TCP). V. cholerae is also a natural inhabitant of the marine environment, where it forms biofilms o...
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Sensing its changing environment is key for Vibrio cholerae when making the transition from an aquatic lifestyle to one more suited to a human host. An inverse correlation between motility and virulence gene expression has been reported, with the NADH : ubiquinone oxidoreductase system which powers motility by generating a sodium-motive force, playing a pivotal role. Recent studies have demonst...
متن کاملA novel regulatory protein involved in motility of Vibrio cholerae.
The facultative pathogen Vibrio cholerae is the causative agent of the human intestinal disease cholera. Both motility and chemotaxis of V. cholerae have been shown to contribute to the virulence and spread of cholera. The flagellar gene operons are organized into a hierarchy composed of four classes (I to IV) based on their temporal expression patterns. Some regulatory elements involved in fla...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1975
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.11.5.890-897.1975